Gonzo is delighted to be asked to accompany Electric Mayhem to the Rock and Roll Hall of Fame Ceremony, and he and Camilla wear their finest for the occasion. The evening is going great until Ozzy Osbourne takes the stage after being inducted and spies Camilla in the crowd. Despite his older age and fading health that old dragon inside him is roused, and he leaps into the crowd and grabs the chicken, biting her head off. Gonzo takes a chunk out of Ozzy in retaliation without realizing that Ozzy has had rabies for decades with no outward signs or symptoms, having been tempered by the constant steady state of alcohol and drugs in his system.
Almost immediately Gonzo begins exhibiting strange behaviors, and after some tests Dr. Honeydew determines he has contracted Muppet Rabies, a dangerous new strain that while not fatal to Gonzo can be lethal if transmitted to other Muppets. After Animal breaks Gonzo out of quarantine for shits and gigs and is hastily bitten by him as thanks a night of terror in the Benny Vandergast Memorial Theater begins, as Gonzo stalks and attacks his compatriots one by one- comeuppance for calling him a Weirdo all these years.